Software engineering radio is an excellent podcast full of in-depth information for developers; contains high quality content different from what you usually find online.
GeneralNoSQL and MongoDB with Dwight Merriman
Top 10 Architecture Mistakes with Eoin Woods
Being a consultant - honest, informal and funny
Software Craftsmanship with Bob Martin - concentrated motivation
Stefan Tilkov on REST - quite practical
Singularity research OS - microkernels, safety, static code analysis
ScalaMartin Odersky on Scala - great interview with the author of Scala
Scala Update with Martin Odersky - second half provides insights into possible future of programming
Btw, Markus Völter (the guy behind se-radio) also does a podcast on technology and science. Software engineer talking to a Nuclear fusion expert - what could we want more? ;) I really enjoyed the following episodes:
Astrobiology at the NASA Astrobiology Institute
Quantum computing - kudos for mentioning the "next technical revolution"
Nuclear Fusion at MPI für Plasmaphysik
Please help me find great episodes - if you know about an episode that you really enjoyed, post it into comments. Thanks!